Endocrine Abstracts

Introduction: The increased rate of thyroid malignancy as well as incidental and subcentimeter thyroid nodules have been attributed to increasing use of high-resolution US which can detect the non-palpabl or subcentimeter (maximum diameter ≤1 cm) thyroid nodules. We aimed to evaluate the sonographic features of the tyroid nodules between ≤1 cm and > 1 cm according the histopathology results and to determine the ultrasonographical predictive factors for malignan...

Introduction: Ocular changes are common in various endocrine disorders. However, there are only few studies reporting ocular changes in patients with primary hyperparathyroidism (PHPT). Here, we examined central corneal thickness (CCT) and retinal thickness (RT), intraocular pressure (IOP) and their relationships with serum intact parathyroid hormone (iPTH), calcium (Ca), and phosphorus levels in PHPT patients.Methods: Thirty-seven patients with PHPT wer...

Introduction: Radioactive iodine (RAI) therapy is widely used in the treatment of hyperthyroidism especially in patients with Graves’ disease (GD), toxic multinodular goitre (TMNG), and toxic adenoma. RAI may lead to worsening of the autoimmunity with the elevation of TSH-receptor antibody (TRAB). In this study, we aimed to compare the effects of surgery or RAI treatment on TRAB.Methods: Hyperthyroid patients were divided into three groups; patients...

Introduction: Patients with parathyroid carcinoma (PCA) and synchronous disease in other parathyroid glands have been reported in the literature. Here, we report a patient who had persistant hypercalcemia after operated from parathyroid carcinoma and improvement of hypercalcemia after the subsequent operation from atypically localised parathyroid adenoma.Case report: A 62-year-old man presented with a history of headache, fatigue, and nervousness. Labora...

Introduction: Primary hyperparathyroidism (PHPT) is a prevalent endocrinologic disease and the most common cause of hypercalcemia. PHPT usually affects the elderly. PHPT younger than 40 years of age is less frequent. In young patients especially for ones younger than 30 years of age, screening for familial syndromes such as MEN 1 and MEN 2A is recommended. However, in most of the cases genetic tests are negative and evidence for other endocrine components are absent. Herein th...

Background: Fine needle aspiration biopsy (FNAB) and Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) have proven to be the most valuable diagnostic procedure for preoperative discrimination of benign and malignant thyroid nodules. Thyroid surgery may cause regional scarring and some degree of fibrotic process which may result in problems when collecting FNAB samples and evaluating the cellular abnormalities. In this study, we aimed to determine whether the Bethesd...

Objective: To verify whether tissue Doppler imaging (TDI) could contribute to a better understanding of the natural history of cardiomyopathy in active Cushing’s disease (CD), through its enhanced sensitivity to diastolic dysfunction, and identifying preliminary regional signs of systolic dysfunction, before the appearance of clinical symptoms of cardiac pathologies.Methods: Eleven women with newly diagnosed CD, and 15 control cases, purposely match...

Objective: Ultrasound (US) guided percutaneous laser ablation (PLA) is a new procedure utilized to decrease nodule volume in symptomatic thyroid nodules, to provide euthyroidism in autonomous hyperfunctioning thyroid nodules, and to decrease compressive symptoms palliatively in malignant nodules. Standard treatment protocol in symptomatic benign hypoactive thyroid nodules is surgery, if needed LT4 suppression, and radioiodine treatment in certain applications. We applied PLA t...

Introduction: Ectopic adrenocorticotropic hormone (ACTH) secretion is a less common cause of Cushing syndrome(CS) and is seen in 5 to 10% of patients with endogenous hypercortisolism. The most common types are bronchial carcinoids and small cell lung carcinoma. However, in approximately 10–20% of the cases, overt tumor cannot be found. Here, we described two patients with catastrophic hypercorticolism associated with ectopic CS and who were treated with bilateral adrenale...

Aim: The aim of this study is to correlate the histopathological cell types and morphologic features of parathyroid neoplasms with ultrasound(US) images and laboratory findings, and also gain more information about the clinical importance of these results.Materials and methods: The parathyroid lesions of 57 patients who were operated for hyperparathyroidism were sampled on saggital plane. The slides were scanned on high resolution and digital whole slide...